Treatments and Trials

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Updated: 57 min 47 sec ago

Ibrutinib plus CD19-specific CAR T-cell therapy may benefit patients with relapsed or refractory CLL

03 December 2018
Administration of ibrutinib beginning 2 weeks prior to leukapheresis and continuing until 3 months after CD19-specific chimeric antigen receptor T-cell therapy appeared well tolerated among patients with relapsed or refractory chronic lymphocytic leukemia, according to retrospective study results presented at ASH Annual Meeting and Exposition. ...

Summary of UK CLL Trials Portfolio ~ November 2018

18 November 2018
The summary of current CLL trials has been updated and is available by following the link below

A Phase II Study of Curcumin and Vitamin D in Previously Untreated Patients with Early Stage Chronic Lymphocytic Leukemia (CLL) or Small Lym

01 November 2018
Background: Current therapies for CLL/SLL have frequent toxicities, are non-curative, and several trials have demonstrated that early treatment of the disease doesn?t result in longer overall survival. In high doses, both curcumin (CM), from turmeric, and vitamin D (VD) have been shown to be safe in multiple clinical trials of solid tumors. Curcumin was shown to disrupt CLL cell interactions with the microenvironment, induce apoptosis independent of DNA damage, and upregulate vitamin D receptor...

Dr. I. Flinn...Recognizing the Side Effects of Newly Approved CLL Therapies

19 October 2018
Today we are discussing the management of patients with chronic lymphocytic leukemia (CLL), including incorporating the newest approved therapies for CLL: duvelisib and venetoclax.
We are joined by Dr. Ian Flinn, a hematologist/oncologist and the director of the Blood Cancer Research Program at Sarah Cannon Research Institute in Tennessee. Dr. Flinn treats patients with CLL and has taken part in many clinical trials of agents in development for the disease.

Duvelisib has marked response, survival benefit in difficult-to-treat leukemia and lymphoma

04 October 2018
"The way we treat patients with CLL is changing rapidly as we move from standard chemotherapy-based approaches to more targeted therapies," said principal investigator Ian W. Flinn, MD, Ph.D., Director of the Lymphoma Research Program at Sarah Cannon Research Institute in Nashville. "Based on these data, duvelisib may offer a new treatment option for patients who otherwise may have limited options."
In sub-group analyses, researchers found duvelisib worked just as well as ofatumumab among the...

Live Ask the Expert Session today

27 September 2018
At the top of the hour at 8 pm UK time, 3pm Eastern, noon Pacific, I'll host a live Ask the Expert CLL session with expert DR. Jeff Sharman. You can still register!

Green tea as drink or capsules and recommended dose, product

23 September 2018
I have read that green tea is helpful with CLL. I was wondering if you would take this as a capsule or drink it (tea). If so, what is the recommended dosage? Which brand/product do you recommend? So far, no symptoms so doctor wants to wait for treatment.
What do you recommend to try? Home remedies?

Title changed from CLL so content can be more easily found - Admin

Visit to MD Anderson- On Waiting List for Ibrutinib Venetoclax clinical trial

20 September 2018
Hello friends! I survived MD Anderson; I'm an introvert and it was very uncomfortable for me to be there amongst those crowds all day. The staff were lovely, though, and I enjoyed my visit with Dr. Thompson.
The good news is twofold. First, I don't have Richter's Transformation or Lymphoma, they told me that that the disease is progressing fast because I am unmutated IGHV. So, I'm going to tell my brother that he was wrong when we were kids, I'm not a mutant! ;p
Second, I am first on the...

Any positive transplant stories 60+?

18 September 2018
I've got a CLL buddy who has just been diagnosed with myelodysplastic syndrome, which is basically bone marrow failure. I'm not clear if this is transformation of her CLL or a secondary malignancy. Either way, she is facing a decision about undergoing an autologous bone marrow transplant.
She is in her late 60s which is on the cusp of eligibility for the procedure. She is physically fit, eats right, and has no other comorbidities that I know of. She has outstanding care at Lombardi Cancer...

UK CLL Trials Portfolio as of July 2018

28 August 2018
An updated list of UK CLL trials as of Jul 2018 can be found here