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Updated: 9 hours 4 min ago

Mode of Progression After Frontline Treatment Predicts Clinical Outcomes in Patients With CLL

13 July 2019
Not only is CLL heterogeneous in watch and wait, that's also the case after treatment. An analysis of over 2,000 patients from three German CLL Study Group clinical trials has identified that unfit patients developing lymphadenopathy (swelling nodes) have a significantly lower median overall survival (OS) than fit patients or patients that develop increasing absolute lymphocyte counts. The authors concluded that “the results suggest that progression by lymphadenopathy is associated with a...

Clinical trial results & reviews of new treatments for CLL written in easy to understand terms

28 June 2019
Anyone interested in reading a weekly update of the latest breaking news for CLL may want to sign up to get emails from this source:
Here are the three links for the articles mentioned in the picture above:
Here is a sample of the Ibrutinib and Venetoclax write up:
Combining ibrutinib and venetoclax...

CLLSA Bournemouth Members Conference report 18 May 2019 - videos embedded together with full report

26 June 2019
The Bournemouth Members Conference summary report has now been updated to includes embedded videos of the presentations, nearly 10gb, of very interesting content.
Most of the powerpoint have been made available at the bottom of the report . A couple are missing and will be added when available. A full report is also attached at the the bottom of the report including tips from the table discussions.

There’s a whole world inside of you: a guide to microbiome research

20 June 2019
Why doesn't one diet suit all of us? Why do some of us benefit from pre and probiotics, while they can be ineffective or even dangerous for others? Why do some of us succumb to C difficile infections while on antibiotics (particularly in hospital) while others don't? Why do medications work for some and not others? Many of the answers are being found in the study of metabolomics and the microbiome. 'As each person’s metabolic profile and microbiome is entirely unique – much like a...

Move over MRD Negative and make way for MRD Undetectable

18 June 2019
As Dr Brian Koffman mentioned here: part of his contribution to the European Hematology Association (EHA) 2019 Amsterdam congress was as a panel member on a satellite event sponsored by the MRD Testing Collaborative, namely the Impact and Barriers to MRD (Minimal Residual Disease) testing. My wife and I were thrilled to be invited to this session by Dr Koffman and his wife Patty and to be able to spend some time with...

Yale study uncovers how gut bacteria can affect whether drugs work or not

05 June 2019
More mysteries of how our gut microbiome can affect treatment responses:
"It's still quite a mystery to scientists why certain drugs work well in some people and are completely ineffective in others. Work by a team of researchers from Yale University suggests a person's unique gut bacteria population could affect how different oral drugs are metabolized, and a new study, for the first time, has measured how a number of different bacteria interact with over 200 common medications.


The future is looking brighter for untreated CLL patients.

19 May 2019
Non chemo therapies for untreated CLL begin to gain approval.
For those of us on Watch and Wait, the future is looking bright recent trials in the UK Clarity and Flair with Ventalax in combination with other targeted therapies have shown very promising results. Only time will tell as CLL progresses so slowly but I hope and pray this turns towards a cure in the next 5 years

Bacteria may not be the only cause of tooth decay

06 May 2019
Neutrophils may be implicated in tooth decay too